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Yes treatment with reglan metoclopramide for prolonged period of time or in high doses can cause tardive dyskinesia- a seriouse often irreversible movement disorder.

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Reglan Injection is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.

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Metoclopramide is contraindicated in patients with pheochromocytoma because the drug may cause a hypertensive crisisprobably due to release of catecholamines from the tumorSuch hypertensive crises may be controlled by phentolamine.

The safety profile of metoclopramide in adults cannot be extrapolated to pediatric patientsDystonias and other extrapyramidal reactions associated with metoclopramide are more common in the pediatric population than in adultsSee WARNINGS and ADVERSE REACTIONSExtrapyramidal Reactions

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reglan injection metoclopramide injection may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and or small intestine.

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