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In hemodynamic studies in patients with essential hypertensionblood pressure reduction was accompanied by a reduction in peripheral arterial resistance with little or no change in cardiac output and in heart rateIn a study in 9 hypertensive patientsfollowing administration of lisinoprilthere was an increase in mean renal blood flow that was not significantData from several small studies are inconsistent with respect to the effect of lisinopril on glomerular filtration rate in hypertensive patients with normal renal functionbut suggest that changesif anyare not large.

Drugs called angiotensin receptor blockersARBssuch as losartanbrand nameCozaarcandesartanAtacandeprosartanTevetenirbesartanAvaprotelmisartanMicardisand valsartanDiovanare commonly used to treat heart failureWe asked whether ARBs reduced deathor severe disability as assessed by hospital admission for any reason versus an inert substanceplaceboor another class of drugs called ACE inhibitorssuch as ramiprilAltacecaptoprilCapotenenalaprilVasotecfosinoprilMonoprillisinoprilPrinivilZestriland quinaprilAccuprilWe also asked whether combining an ARB with an ACE inhibitor is more effective than an ACE inhibitor alone in reducing deathdisabilityor hospital admission for any reasonThe scientific literature was searched to find all trials that had assessed these questions.

HOW TO USETake this medication by mouth with or without food as directed by your doctorusually once daily.If you are using the suspension form of this medicationshake the bottle well before each doseCarefully measure the dose using a special measuring device/spoonDo not use a household spoon because you may not get the correct dose.The dosage is based on your medical condition and response to treatmentFor childrenthe dosage is also based on weight.Use this medication regularly in order to get the most benefit from itTo help you remembertake it at the same time each dayIt is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick.For the treatment of high blood pressureit may take 2 to 4 weeks before you get the full benefit of this medicationFor the treatment of heart failureit may take weeks to months before you get the full benefit of this medicationTell your doctor if your condition does not improve or if it worsenssuch as your blood pressure readings remain high or increase

HypotensionSymptomatic hypotension has occurred after administration of lisinoprilusually after the first or second dose or when the dose was increasedIt is more likely to occur in patients who are volume depleted by diuretic therapydietary salt restrictiondialysisdiarrhea or vomiting or possibly in patients with renin-dependent renovascular hypertensionsee DosageIn patients with severe congestive heart failurewith or without associated renal insufficiencyexcessive hypotension has been observed and may be associated with oliguria and/or progressive azotemiaand rarely with acute renal failure and/or deathBecause of the potential fall in blood pressure in these patientstherapy should be started under very close medical supervisionusually in a hospitalSuch patients should be followed closely for the first 2 weeks of treatment and whenever the dose of lisinopril and/or diuretic is increasedSimilar considerations apply to patients with ischemic heart or cerebrovascular disease in whom an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accidentsee Adverse Effects

This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.

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