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Several reports have documented the efficacy of methotrexate in patients with steroid-dependent sarcoidosis.

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This medication can affect sperm productionan effect that may lower male fertilityConsult your doctor for more details.

Serious side effects can be reduced to a minimum by following these important instructions:

This medicine can pass into body fluidsurinefecesvomitCaregivers should wear rubber gloves while cleaning up a patient’s body fluidshandling contaminated trash or laundry or changing diapersWash hands before and after removing glovesWash soiled clothing and linens separately from other laundry.

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coadministration, in 30 patients, of leflunomide 100 mg day x 2 days followed by 10 to 20 mg day with methotrexate 10 to 25 mg week, with folate demonstrated no pharmacokinetic interaction between the two drugs.

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