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Gabapentin did not demonstrate mutagenic or genotoxic potential in three in vitro and four in vivo assaysIt was negative in the Ames test and the in vitro HGPRT forward mutation assay in Chinese hamster lung cellsit did not produce significant increases in chromosomal aberrations in the in vitro Chinese hamster lung cell assayit was negative in the in vivo chromosomal aberration assay and in the in vivo micronucleus test in Chinese hamster bone marrowit was negative in the in vivo mouse micronucleus assayand it did not induce unscheduled DNA synthesis in hepatocytes from rats given gabapentin.

Dosage adjustment in patients 12 years of age and older with renal impairment or undergoing hemodialysis is recommendedas followssee dosing recommendations above for effective doses in each indication

Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosingGabapentin elimination rate constantplasma clearanceand renal clearance are directly proportional to creatinine clearanceIn elderly patientsand in patients with impaired renal functiongabapentin plasma clearance is reducedGabapentin can be removed from plasma by hemodialysis.

These are not all the possible side effects of NEURONTINFor more informationask your healthcare provider or pharmacist.

Safety and effectiveness of NEURONTIN in the management of postherpetic neuralgia in pediatric patients have not been established.

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