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Simvastatin is a white to off-whitenonhygroscopiccrystalline powder that is practically insoluble in water and freely soluble in chloroformmethanol and ethanolIts structural formula is:

Take this medication regularly in order to get the most benefit from itRemember to take it at the same time each dayIt is important to continue taking this medication even if you feel wellMost people with high cholesterol or triglycerides do not feel sick.

Caution should be used when prescribing with VYTORINsee WARNINGS AND PRECAUTIONS and Fenofibratese.gFenofibrate And Fenofibric Acid

Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysisThis is accompanied by elevations in creatine kinasemyoglobinuriaand proteinuriaas well as renal failureExperience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozilniacincyclosporineor erythromycin may increase the incidence and the severity of musculoskeletal side effects.

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